What is Male Infertility?
- Male infertility refers to a male’s inability to cause a successful pregnancy in a fertile female.
- Male infertility can be due to low sperm production, abnormal sperm function or blockages that prevent the delivery of sperm. Illnesses, injuries, chronic health problems, lifestyle choices and other factors can also play a role in causing male infertility.
- Male Infertility Factor is the primary cause of infertility in 20-70% of the cases1. It is estimated that this condition affects 30 million men globally1.
- High levels of oxidative stress can damage normal spermatozoa by inducing lipid peroxidation and DNA damage and are associated with poor sperm function and subfertility.
Current practice guidelines recommend a “Semen Analysis Test” in patients suspected of Male Infertility Factor due to:
- 12 months of unprotected intercourse without pregnancy (success).
- Anatomical issues involving blocking or obstruction to transport of sperm.
- Chronic infections and or immunocompromised conditions.
- Lifestyle issues associated with health, environmental, or age factors.
Under the Advanced Semen Analysis Testing, including oxidative stress testing, for idiopathic or unknown cause is particularly indicated in patients with the following etiologies:
- Idiopathic male infertility
- Male partners of Recurrent Pregnancy Loss or history of failed IUI or IVF cycles
- Infection of male accessory glands (example: prostatitis)
- History of smoking
- Older males – over the age of 40
- Agarwal et al. Reproductive Biology and Endocrinology (2015)
- Allied Market Research Report (2012)
- Sigman M, Howards SS (1998). Male infertility. In: Walsh PC, Retik AB,Vaughan Jr ED, Wein AJ,editors. Campbell’s Urology (7th ed.) Philadelphia:WB Saunders Company. pp.1287-1320
- ESHRE/ESGE CONUTA Group/ Royal College of Obstetricians and Gynaecologists/ SIGO – AOGOI – AGUI – Section 9 & 16